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Residue Chemistry

Smithers Viscient provides GLP-compliant residue chemistry studies for registration and environmental monitoring needs.

Download the Residue Chemistry technical brief

Our analytical chemists have expertise in method development and method validation, and can design and implement fully customizable multi-residue testing programs for both active ingredients and metabolites. Smithers Viscient has developed HPLC and GC methods for a wide variety of matrices, including plant materials, soil, water, air, processed food, animal feed and animal tissues. These methods are fully validated according to the latest guidelines. Our experienced chemists quantitatively measure the active ingredient (AI) and its metabolites – or the degradation products produced from the AI.

OPPTS Guidelines supported include:

860.1300 – Nature of the Residue–Plants, Livestock (August 1996)
860.1340 – Residue Analytical Method (August 1996)
860.1360 – Multiresidue Method (August 1996)
860.1380 – Storage Stability Data (August 1996)
860.1400 – Water, Fish, Irrigated Crops (August 1996)
860.1460 – Food Handling (August 1996) (PDF)
860.1480 – Meat/Milk/Poultry/Eggs (August 1996)
860.1500 – Crop Field Trials (August 1996) (
860.1520 – Processed Food/Feed (August 1996)
835.6100 – Terrestrial Field Dissipation (October 2008)
875.2100 – Foliar Dislodgeable Residue Dissipation (February 1996)
875.2200 – Soil Residue Dissipation (February 1996)

 OECD Guidelines supported include:

Test No. 509: Crop Field Trial
Test No. 508: Magnitude of the Pesticide Residues in Processed Commodities
Test No 506: Stability of Pesticide Residues in Stored Commodities
Test No. 504: Residues in Rotational Crops (Limited Field Studies)
505: Residues in Livestock

All methods used are in full compliance with SANCO/825/00 rev.6 (2000) and OPPTS 860.1340.  

Smithers Viscient delivers timely, cost-effective sample generation and analysis. We can coordinate and conduct field trials in growing regions across the United States and Europe. Samples are processed and analyzed at our laboratories.

Services

  • Analytical methods development  and validation 
  • Field dissipation
  • Field trials in collaboration with field contractors
  • Decline of residue (DEC), magnitude of residue at harvest (MOR) Groundwater and surface water studies 
  • Dislodgeable foliar residuestudies
  • Worker exposure studies
  • Magnitude of residue
  • Maximum residue limits (MRL)/Import tolerance
  • Independent laboratory validation (ILV)
  • Feeding Studies
  • Fish and shellfish residue studies
  • Laboratory-scale fumigation studies
  • Food process control and monitoring
  • Human food safety and residue analysis
  • Storage stability/product shelf life
  • Analysis of water for aqueous studies (fish, daphnia, algae)
  • Verification of dosing / application in animal studies
  • Sample receipt, inventory, pre-processing, and frozen storage
  • Aged samples originating from 14C-metabolism, field or feeding studies (plant, animal) or dissipation (soil, sediment, water) studies
  • Modeling kinetic data—generated from metabolism studies and environmental fate evaluations
  • Degradation pathways

Specialized Instrumentation

Smithers Viscient has a variety of instrumentation, including an LCMSMS with Qtrap used for metabolite ID. Other equipment includes 5 mass specs, 12 HPLCs, 6 GCs and 2 GCMS. Our diverse instrumentation allows us to analyze a wide variety of chemicals with a high and cost-effective throughput of samples.

Instrumentation includes:

  • HPLC with UV, DAD. 14C, and ELSD Detectors,
  • LC/MS/MS (Sciex API 3000, 4000, 4000 Q trap and 5000) Micromass Quattro Micro
  • UPLC (Waters Acuity)
  • Gas Chromatography (GC) with EC, NPD, FID, MSD
  • Headspace injection System
  • Capillary Electrophoresis
  • Ion Chromatography
  • Ultraviolet-Visible Spectroscopy
  • Fluorescence Spectroscopy
  • Fourier Transform Infrared Spectroscopy
  • Raman Spectroscopy
  • One- and Two-Dimensional Electrophoresis
  • Accelerated Solvent Extraction
  • ASE Extractors (Dionex 200)

Storage Facilities

  • Continuously monitored, environmentally controlled storage
  • Freezer rooms monitored to record specimen and air temperature set to maintain temperatures below -18°C
  • Cold room set to maintain 4°C